Normalization of Hyperglycaemia by Oral Vanadyl Sulfate Does Not Reverse Diabetes-Induced Protection against Cisplatin Nephrotoxicity in Streptozotocin-Diabetic Rats
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چکیده
منابع مشابه
Effects of Vanadyl Sulphate on Glucose Homeostasis in Severe Diabetes Induced by Streptozotocin in Rats
Background: There is not any in vivo studies that shows inducing of euglycemia by vanadyl is independent from plasma insulin. Therefore in the present study we planned to investigate the antidiabetic effects of vanadyl in diabetic rats. Materials and Methods: Rats became severely diabetic by an IV injection of 50-55mg/kg streptozotocin (STZ), 15 days after the injection, the blood glucose of ...
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BACKGROUND Diabetes mellitus can change the risk of developing cancer. Cisplatin (CP) is a common antineoplastic drug. The major side effect of CP is nephrotoxicity. Gamma amino butyric acid (GABA) is an antioxidant agent that may have a protective role against CP-induced nephrotoxicity. The aim of the present study was to investigate the role of GABA in CP-induced nephrotoxicity in hyperglycem...
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BACKGROUND Cisplatin (CP) is accompanied with a nephrotoxicity. L-arginine (LA) plays an important role in the regulation of renal function. The present study was designed to investigate the protective role of LA supplementation in CP-induced nephrotoxicity in a diabetic rat's model. MATERIALS AND METHODS Sixteen adult female and male Wistar rats were used and they received a single dose of s...
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ژورنال
عنوان ژورنال: Pharmacology & Toxicology
سال: 1999
ISSN: 0901-9928,1600-0773
DOI: 10.1111/j.1600-0773.1999.tb00087.x